Technology Process of N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine
There total 4 articles about N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 - 5 ℃;
for 1.5h;
With
sodium azide;
In
water;
at 0 - 5 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 2,2-dimethoxy-propane / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Reflux
2.1: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux
3.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
4.1: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux
5.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
5.2: 3 h / 0 - 20 °C
With
iron(III) chloride; copper(l) iodide; sulfuric acid; potassium carbonate; hydrazine hydrate; 2,2-dimethoxy-propane; sodium hydroxide; N,N`-dimethylethylenediamine; sodium nitrite;
In
1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; butan-1-ol;
3.1: Ullmann reaction;
DOI:10.1002/cmdc.201100304
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux
2.1: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux
3.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C
3.2: 3 h / 0 - 20 °C
With
iron(III) chloride; copper(l) iodide; sulfuric acid; potassium carbonate; hydrazine hydrate; N,N`-dimethylethylenediamine; sodium nitrite;
In
1,4-dioxane; methanol; water;
1.1: Ullmann reaction;
DOI:10.1002/cmdc.201100304