N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

Base Information

Chemical Name:N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine
CAS No.:1346617-86-4
Molecular Formula:C₃₀H₃₁N₉
Molecular Weight:517.636
Hs Code.:

Synonyms:N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

There total 12 articles about N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 933986-40-4
1-(4-ethynylbenzyl)-4-methylpiperazine

: 1346617-84-2
N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine

: 1346617-86-4
N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

Guidance literature:: With L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate; In water; tert-butyl alcohol; at 20 ℃; for 24h;
DOI:10.1002/cmdc.201100304

Reference yield:

: 152460-10-1
6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 1346617-86-4
N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate / water; tert-butyl alcohol / 24 h / 20 °C

With L-ascorbic acid sodium salt; sulfuric acid; copper(II) sulfate pentahydrate; sodium nitrite; In water; tert-butyl alcohol;
DOI:10.1002/cmdc.201100304

Reference yield:

: 350-03-8
methyl-3-pyridylketone

: 1346617-86-4
N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,2-dimethoxy-propane / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C / Reflux

2.1: sodium hydroxide / butan-1-ol / 4 h / 120 °C / Reflux

3.1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere; Reflux

4.1: iron(III) chloride; hydrazine hydrate / methanol / 6 h / 80 °C / Reflux

5.1: sulfuric acid; sodium nitrite / water / 0.5 h / 0 °C

5.2: 3 h / 0 - 20 °C

6.1: L-ascorbic acid sodium salt; copper(II) sulfate pentahydrate / water; tert-butyl alcohol / 24 h / 20 °C

With iron(III) chloride; copper(l) iodide; L-ascorbic acid sodium salt; sulfuric acid; copper(II) sulfate pentahydrate; potassium carbonate; hydrazine hydrate; 2,2-dimethoxy-propane; sodium hydroxide; N,N`-dimethylethylenediamine; sodium nitrite; In 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; tert-butyl alcohol; butan-1-ol; 3.1: Ullmann reaction;
DOI:10.1002/cmdc.201100304