2-Methoxytetrahydrofuran

Base Information

• Chemical Name: 2-Methoxytetrahydrofuran
• CAS No.: 13436-45-8
• Molecular Formula: C5H10O2
• Molecular Weight: 102.133
• Hs Code.: 2932190090
• European Community (EC) Number: 236-568-3
• DSSTox Substance ID: DTXSID50928588
• Nikkaji Number: J317.882J
• Mol file: 13436-45-8.mol

Synonyms:2-Methoxytetrahydrofuran;2-methoxyoxolane;13436-45-8;Furan, tetrahydro-2-methoxy-;FURAN,TETRAHYDRO-2-METHOXY-;EINECS 236-568-3;2-methoxy-tetrahydro-furan;2-methoxy-tetrahydrofuran;SCHEMBL300796;2-Methoxytetrahydrofuran, 99%;DTXSID50928588;AKOS006274054;AS-58090;A937142

Chemical Property of 2-Methoxytetrahydrofuran

Chemical Property:

• Vapor Pressure: 26.1mmHg at 25°C
• Refractive Index: 1.417
• Boiling Point: 112 °C at 760 mmHg
• Flash Point: 7.8 °C
• PSA: 18.46000
• Density: 0.96 g/cm³
• LogP: 0.76930
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 102.068079557
• Heavy Atom Count: 7
• Complexity: 54

Purity/Quality:

98%Min ^*data from raw suppliers

2-Methoxytetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCCO1
• Uses: 2-Methoxytetrahydrofuran is a reactant in the preparation of ruthenium(III) chloro benzimidazolylmethylamine derivative complexes as oxidation catalysts.

Technology Process of 2-Methoxytetrahydrofuran

There total 17 articles about 2-Methoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

n-Pent-4-enyl alcohol (821-09-0) → 2-methoxytetrahydrofuran (13436-45-8)

Guidance literature:

With titanium silicate; dihydrogen peroxide; In acetone; at 24.9 ℃;

DOI:10.1039/a708528a

Reference yield: 98.0%

dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 2-methoxytetrahydrofuran (13436-45-8) + 4-butanolide (96-48-0) + propan-1-ol (71-23-8) + 2-(4'-hydroxybutoxy)-tetrahydrofuran (64001-06-5) + Butane-1,4-diol (110-63-4) + butan-1-ol (71-36-3)

Guidance literature:

With hydrogen; copper catalyst, T 4489, Sud-Chemie AG, Munich; at 150 - 280 ℃; under 187519 Torr; Neat liquid(s) and gas(es)/vapour(s);

Reference yield: 79.1%

dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 2-methoxytetrahydrofuran (13436-45-8) + 4-butanolide (96-48-0) + propan-1-ol (71-23-8) + 1-methoxy-1,4-butanediol + 2-(4'-hydroxybutoxy)-tetrahydrofuran (64001-06-5) + 4-hydroxy-butanoic acid 4-hydroxybutyl ester + Butane-1,4-diol (110-63-4) + 4-hydroxybutyraldehyde (25714-71-0) + methyl 4-hydroxybutanoate (925-57-5) + butan-1-ol (71-36-3)

Guidance literature:

With hydrogen; at 190 ℃; under 46504.7 Torr; Gas phase;

upstream raw materials:

2,5-dihydrofuran

methanol

4-hydroxybutyraldehyde

tetrahydrofuran

Downstream raw materials:

hexacarbonyl(μ-3-η1-anti-(methoxycarbonyl)-η3:η1-allyl)diruthenium(Ru-Ru)

dimethyl glutaconate

6-Methoxy-2H-pyran-2-on

2-(3-phenylprop-1-yl)-tetrahydrofuran

Refernces

• 1、 Di Salvo, Andrea,David, Marc,Crousse, Benoit,Bonnet-Delpon, Daniele. "Self-promoted nucleophilic addition of hexafluoro-2-propanol to vinyl ethers". . p. 118 - 124. Retrieved 2006.
• 2、 Hiegel, Gene A.,Gilley, Cynthia B.. "The oxidation of primary alcohols to methyl esters and diols to lactones using trichloroisocyanuric acid". . p. 2003 - 2009. Retrieved 2007/10/03.