3-(5,7-DiMethyl-[1,2,4]triazolo[1,5-a]pyriMidin-2-yl)propanoic acid

Base Information

• Chemical Name: 3-(5,7-DiMethyl-[1,2,4]triazolo[1,5-a]pyriMidin-2-yl)propanoic acid
• CAS No.: 901735-11-3
• Molecular Formula: C₁₀H₁₂N₄O₂
• Molecular Weight: 220.231
• Mol file: 901735-11-3.mol

Synonyms:3-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanoic acid

Chemical Property of 3-(5,7-DiMethyl-[1,2,4]triazolo[1,5-a]pyriMidin-2-yl)propanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

3-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanoicAcid ^*data from reagent suppliers

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Technology Process of 3-(5,7-DiMethyl-[1,2,4]triazolo[1,5-a]pyriMidin-2-yl)propanoic acid

There total 3 articles about 3-(5,7-DiMethyl-[1,2,4]triazolo[1,5-a]pyriMidin-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

succinic acid anhydride (108-30-5) + 1-aminoguanidine hydrochloride (1937-19-5,16139-18-7) + acetylacetone (123-54-6,81235-32-7) → 3-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanoic acid (901735-11-3)

Guidance literature:

succinic acid anhydride; 1-aminoguanidine hydrochloride; at 190 ℃; for 1h;

With sodium hydroxide; In water; at 120 ℃; for 1.5h;

acetylacetone; With acetic acid; In ethanol; for 7h; Reflux;

DOI:10.1248/cpb.c17-00836

Reference yield:

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde (55293-96-4) → 3-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanoic acid (901735-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine; pyridine / 100 °C

2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol

With piperidine; pyridine; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; 1: |Knoevenagel Condensation;

DOI:10.1021/op400236r

Reference yield:

C10H10N4O2 → 3-(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)propanoic acid (901735-11-3)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol;

DOI:10.1021/op400236r

upstream raw materials:

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde

succinic acid anhydride

1-aminoguanidine hydrochloride

acetylacetone

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