tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

Base Information

Chemical Name:tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane
CAS No.:148903-86-0
Molecular Formula:C₃₈H₄₈O₄Si₂
Molecular Weight:624.968
Hs Code.:

Synonyms:tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

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Chemical Property of tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

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Technology Process of tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

There total 4 articles about tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 51255-17-5,51255-18-6,60134-26-1,89577-26-4,96038-80-1,96039-31-5,144301-84-8,144301-85-9
1-O-methyl-2-deoxy-D-ribofuranoside

: 148903-86-0
tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1021/acs.joc.1c00706

Reference yield: 58.0%

: 67-56-1
methanol

: 2923-28-6
silver trifluoromethanesulfonate

: 6-N-benzoyl-3',5'-O-bis-tert-butyldiphenylsilyl-2'-deoxyadenosine

: C₁₂H₉N₅O*Ag⁽¹⁺⁾

: 2C₁₂H₉N₅O*Ag⁽¹⁺⁾

: 148903-86-0
tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

Guidance literature:: silver trifluoromethanesulfonate; 6-N-benzoyl-3',5'-O-bis-tert-butyldiphenylsilyl-2'-deoxyadenosine; With p-methylbenzenesulfenyl chloride; In dichloromethane; at -40 ℃; for 3h;

methanol;
DOI:10.1002/asia.201403319

Reference yield:

: 22900-10-3,35536-75-5,36792-85-5,113890-34-9,113890-37-2,133813-23-7
2-deoxy-D-ribose

: 148903-86-0
tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-5-methoxytetrahydrofuran-2-yl)methoxy)diphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / diethyl ether / 0.25 h

2: pyridine / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; In diethyl ether;
DOI:10.1021/ja00066a056