1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

Base Information

Chemical Name:1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide
CAS No.:1471178-11-6
Molecular Formula:C₁₉H₁₃F₃N₄O₂
Molecular Weight:386.333
Hs Code.:

Synonyms:1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

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Chemical Property of 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

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Technology Process of 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

There total 8 articles about 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1471177-97-5
ethyl 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate

: 1471178-11-6
1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

Guidance literature:: With hydrazine; In ethanol; at 80 ℃; for 4h;
DOI:10.1016/j.ejmech.2013.07.021

Reference yield: 71.0%

: 116247-30-4
7-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid hydrazide

: 17201-43-3
4-cyanobenzyl bromide

: 1471178-11-6
1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; regioselective reaction;
DOI:10.1016/j.ejmech.2013.07.021

Reference yield:

: 23851-84-5
4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 1471178-11-6
1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: hydrazine / ethanol / 4 h / 80 °C

With potassium carbonate; hydrazine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.07.021