methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate

Base Information

• Chemical Name: methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate
• CAS No.: 251986-49-9
• Molecular Formula: C₁₂H₁₂FNO₄
• Molecular Weight: 253.23
• Mol file: 251986-49-9.mol

Synonyms:methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate

Chemical Property of methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate

There total 1 articles about methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethyl acetylenedicarboxylate (762-42-5) + 4-fluoroaniline (371-40-4) → methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate (251986-49-9)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.3987/COM-99-8629

Reference yield: 94.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-fluoroaniline (371-40-4) + methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate (251986-49-9) → dimethyl 1,3-bis(4-fluorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate (1169473-89-5)

Guidance literature:

With acetic acid; In methanol; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2009.03.071

Reference yield: 88.0%

oxalyl dichloride (79-37-8) + methyl 3-carbomethoxy-3-(4'-fluorophenyl)amino-2-propenoate (251986-49-9) → 4,5-dimethoxycarbonyl-1-(4'-fluorophenyl)-1H-pyrrole-2,3-dione (251986-57-9)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃;

DOI:10.3987/COM-99-8629

upstream raw materials:

dimethyl acetylenedicarboxylate

4-fluoroaniline

Downstream raw materials:

4,5-dimethoxycarbonyl-1-(4'-fluorophenyl)-1H-pyrrole-2,3-dione

6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

dimethyl 1,3-bis(4-fluorophenyl)-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate

methyl 1-(4-fluorophenyl)-4-((4-fluorophenyl)amino)-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate