N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

Base Information

Chemical Name:N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide
CAS No.:205515-56-6
Molecular Formula:C₂₁H₂₂ClN₃O₆S₂
Molecular Weight:512.007
Hs Code.:

Synonyms:N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

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Chemical Property of N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

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Technology Process of N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

There total 6 articles about N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 184040-74-2
3{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid

: 205516-96-7
methyl 3-amino-2,4,6-trimethylphenylacetate

: 205515-56-6
N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

Guidance literature:: 3{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 0.166667h;

methyl 3-amino-2,4,6-trimethylphenylacetate; In N,N-dimethyl-formamide; at 100 ℃; for 15h;
DOI:10.1021/jm9900063

Reference yield:

: 34688-71-6
mesitylacetonitrile

: 205515-56-6
N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 84 percent / 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

2.1: 79 percent / aq. NH₄Cl; Zn / methanol / 4 h

3.1: conc. H₂SO₄ / 15 h / Heating

4.1: 1,1'-carbonyldiimidazole / dimethylformamide / 0.17 h

4.2: 8 percent / dimethylformamide / 15 h / 100 °C

With sulfuric acid; nitric acid; ammonium chloride; acetic acid; 1,1'-carbonyldiimidazole; zinc; In methanol; N,N-dimethyl-formamide; 1.1: Nitration / 2.1: Reduction / 3.1: methanolysis / 4.1: Condensation / 4.2: Substitution;
DOI:10.1021/jm9900063

Reference yield:

: 205517-05-1
2,4,6-trimethyl-3-nitrobenzeneacetonitrile

: 205515-56-6
N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / aq. NH₄Cl; Zn / methanol / 4 h

2.1: conc. H₂SO₄ / 15 h / Heating

3.1: 1,1'-carbonyldiimidazole / dimethylformamide / 0.17 h

3.2: 8 percent / dimethylformamide / 15 h / 100 °C

With sulfuric acid; ammonium chloride; 1,1'-carbonyldiimidazole; zinc; In methanol; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: methanolysis / 3.1: Condensation / 3.2: Substitution;
DOI:10.1021/jm9900063