184040-74-2

Basic information

• Product Name: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-
• Synonyms: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-;3-(N-(4-chloro-3-Methylisoxazol-5-yl)sulfaMoyl)thiophene-2-carboxylic acid;3-[[(4-Chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]-2-thiophenecarboxylic acid
• CAS NO: 184040-74-2
• Molecular Formula: C₉H₇ClN₂O₅S₂
• Molecular Weight: 322.74528
• Mol File: 184040-74-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 556.983°C at 760 mmHg
• Flash Point: 290.653°C
• Appearance: /
• Density: 1.746±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(184040-74-2)
• EPA Substance Registry System: 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-Methyl-5-isoxazolyl)aMino]sulfonyl]-(184040-74-2)

Safety Data

• Hazardous Substances Data: 184040-74-2(Hazardous Substances Data)

Usage

Description

2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]is a complex organic chemical compound characterized by a thiophene ring, a carboxylic acid group, and a sulfonamide linkage. The incorporation of isoxazolyl and chloro-methyl groups within its structure indicates potential antimicrobial or herbicidal properties, while the sulfonamide group hints at its possible use as an antibacterial pharmaceutical agent. Further investigation is required to ascertain its full range of applications and effects.

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]is used as a potential antibacterial agent for its sulfonamide group, which is known to have antimicrobial properties. It may be developed into a pharmaceutical drug to combat bacterial infections, pending further research and clinical trials.
Used in Agricultural Industry:
In the agricultural sector, 2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]is used as a potential herbicide due to its possible antimicrobial properties, which could be effective against unwanted plant growth. Its application could be in the development of new herbicidal formulations to control weeds in various crop cultivations.
Note: The uses listed are speculative based on the chemical structure and common applications of similar compounds. Actual uses may vary and are dependent on the outcomes of further research and development.

InChI:InChI=1/C9H7ClN2O5S2/c1-4-6(10)8(17-11-4)12-19(15,16)5-2-3-18-7(5)9(13)14/h2-3,12H,1H3,(H,13,14)

Upstream product

• 59337-92-7 2-(carbomethoxy)thiophene-3-sulfonyl chloride 
• 184644-72-2 3-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-2-thiophenecarboxylic acid methyl ester 

Downstream Products

• 210421-71-9 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(N-methyl-N'-methoxy)aminocarbonyl-3-thiophenesulfonamide 
• 184036-04-2 N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(4,5-dimethoxy-2-methoxycarbonylphenyl)aminocarbonyl]thiophene-3-sulfonamide 
• 184036-34-8 sitaxentan 
• 184036-18-8 N-(4-chloro-3-methyl-5-isoxazolyl)-2-{[2-cyano-4,5-(methylenedioxy)phenyl]aminocarbonyl}thiophene-3-sulfonamide 
• 215501-60-3 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(2-(3-methoxy-2,4,6-trimethylphenyl)acetyl)-3-thiophenesulfonamide 
• 205515-55-5 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-acetoxymethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide 
• 205515-56-6 N-(4-chloro-3-methyl-5-isoxazolyl)-2-(3-methoxycarbonylmethyl-2,4,6-trimethylphenylaminocarbonyl)thiophene-3-sulfonamide 

Relevant articles and documents

2-aryloxycarbonylthiophene-3-sulfonamides highly potent and ET(A) selective endothelin receptor antagonists

A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy) phenoxycarbonyl]thiophene-3-sulfonamide was identified as a highly selective, potent (IC50= 8.3 nM) and low molecular weight nonpeptide antagonist.

SUBSTITUTED THIOPHENES

Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Sulfonamides and derivatives thereof that modulate the activity of endothelin

Thienyl-, furyl-, pyrrolyl- and phenylsulfonamides, formulations of pharmaceutically-acceptable derivatives thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienyl