1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Chemical Name:1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate
CAS No.:1258976-19-0
Molecular Formula:C₂₄H₂₈N₆O₃S
Molecular Weight:480.591
Hs Code.:

1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Synonyms:1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Chemical Property of 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

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Technology Process of 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

There total 6 articles about 1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 157327-43-0
tert-butyl 5-acetyl-4-hydroxy-3,6-dihydropyridine-1(2H)-carboxylate

: 1258976-18-9
5-(5-hydrazino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)-oxy]benzonitrile

: 1258976-19-0
1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: In ISOPROPYLAMIDE; at 150 ℃; for 1h; Product distribution / selectivity; Irradiation with microwave;

Reference yield: 2.0%

: 1258976-18-9
5-(5-hydrazino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)-oxy]benzonitrile

: tert-butyl 4-acetyl-3-oxo-piperidine-1-carboxylate

: 1258976-19-0
1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: In ethanol; at 20 ℃; for 24h;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 1258440-55-9
5-(5-amino-1,3,4-thiadiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile

: 1258976-19-0
1,1-dimethylethyl 2-(5-{3-cyano-4-[(1-methylethyl)oxy]-phenyl}-1,3,4-thiadiazol-2-yl)-3-methyl-2,4,6,7-tetrahydro-5Hpyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 1 h / 20 - 70 °C

2: hydrazine hydrate / isopropyl alcohol / 2 h / 100 °C / Inert atmosphere

3: ethanol / 24 h / 20 °C

With tert.-butylnitrite; hydrazine hydrate; copper(ll) bromide; In ethanol; isopropyl alcohol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01512