(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

Base Information

Chemical Name:(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid
CAS No.:1246779-20-3
Molecular Formula:C₃₁H₃₆N₂O₇
Molecular Weight:548.636
Hs Code.:

(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

Synonyms:(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

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Chemical Property of (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

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Technology Process of (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

There total 1 articles about (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246779-19-0
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-1,11-dihydroxy-10a,12a-dimethyl-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

: 79-03-8
propionyl chloride

: 1246779-20-3
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

Guidance literature:: (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-1,11-dihydroxy-10a,12a-dimethyl-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid; propionyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With N,N',N'-trimethylenediamine; In dichloromethane; at 20 ℃; for 0.5h;

With hydrogenchloride; In dichloromethane; water;

Reference yield: 26.0%

: 1246779-20-3
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

: 6338-70-1
3-amino-tetrahydrothiophene 1,1-dioxide

: 1246779-24-7
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-{3-[(1,1-dioxidotetrahydrothiophen-3-yl)carbamoyl]phenyl}-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

Guidance literature:: (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

3-amino-tetrahydrothiophene 1,1-dioxide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1246779-20-3
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

: 1668-10-6
glycinamide hydrochloride

: 1246779-21-4
(1R,3aS,3bS,10aR,10bS,11S,12aS)-7-{3-[(2-amino-2-oxoethyl)carbamoyl]phenyl}-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid

Guidance literature:: (1R,3aS,3bS,10aR,10bS,11S,12aS)-7-(3-carboxyphenyl)-11-hydroxy-10a,12a-dimethyl-1-(propanoyloxy)-1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahydrocyclopenta[5,6]naphtho[1,2-f]indazole-1-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

glycinamide hydrochloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; In water; N,N-dimethyl-formamide;