N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline

Base Information

• Chemical Name: N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline
• CAS No.: 1352609-09-6
• Molecular Formula: C₂₄H₂₁N₇
• Molecular Weight: 407.478
• Mol file: 1352609-09-6.mol

Synonyms:N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline

Chemical Property of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline

There total 6 articles about N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-vinylaniline (15411-43-5) + 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde (1352609-91-6) → N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline (1352609-09-6)

Guidance literature:

3-vinylaniline; 4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde; With acetic acid; In 1,2-dichloro-ethane; at 80 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 40 ℃;

Reference yield:

C24H19N7 → N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline (1352609-09-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.03.022

Reference yield:

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone (614750-82-2) → N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline (1352609-09-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide; hydrogen bromide / 2 h / 60 - 70 °C

2.1: ammonium acetate / water; tert-butyl methyl ether; methanol / 3 h / 20 °C

2.2: pH 8

3.1: hydrogenchloride; water / 3 h / 70 °C

3.2: 0 °C

4.1: acetic acid / 1,2-dichloro-ethane / 2 h / 80 °C

4.2: 0 - 40 °C

With hydrogenchloride; ammonium acetate; water; hydrogen bromide; acetic acid; dimethyl sulfoxide; In methanol; tert-butyl methyl ether; water; 1,2-dichloro-ethane;

upstream raw materials:

3-vinylaniline

4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazole-2-carbaldehyde

1-(6-methylpyridin-2-yl)-2-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-ethanone

6-methyl-2-pyridinecarboxaldehyde

Downstream raw materials:

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline sulfate

N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-3-vinylaniline hydrochloride