2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

Base Information

Chemical Name:2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol
CAS No.:1319069-37-8
Molecular Formula:C₁₆H₁₇ClN₄O
Molecular Weight:316.79
Hs Code.:

Synonyms:2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

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Chemical Property of 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

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Technology Process of 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

There total 12 articles about 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319069-35-6
2-(2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-propan-2-ol

: 1679-18-1
4-Chlorophenylboronic acid

: 1319069-37-8
2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

Guidance literature:: 2-(2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-propan-2-ol; 4-Chlorophenylboronic acid; With sodium carbonate; In 1,4-dioxane; water; for 0.0833333h; Inert atmosphere;

dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 1.5h;

Reference yield:

: 1319069-35-6
2-(2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-propan-2-ol

: C₉H₉BrN₄O

: 1679-18-1
4-Chlorophenylboronic acid

: 1319069-37-8
2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

: 2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1319069-33-4
2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid methyl ester

: 1319069-37-8
2-[2-amino-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene; tetrahydrofuran / 3.5 h / -40 - -30 °C

1.2: 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 80 °C / Inert atmosphere

With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; toluene;