5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde

Base Information

• Chemical Name: 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde
• CAS No.: 1313434-56-8
• Molecular Formula: C₂₅H₁₅BrN₂OS
• Molecular Weight: 471.377
• Mol file: 1313434-56-8.mol

Synonyms:5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde

Chemical Property of 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde

There total 10 articles about 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

5,8-dibromo-2,3-diphenylquinoxaline (94544-77-1) + (5-formylthiophen-2-yl)boronic acid → 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde (1313434-56-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In tetrahydrofuran; water; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol2012378

Reference yield:

formic acid (64-18-6) + 5-bromo-8-[5-(1,3-dioxolan-2-yl)thiophen-2-yl]-2,3-diphenylquinoxaline → 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde (1313434-56-8)

Guidance literature:

In toluene; at 80 - 108 ℃; for 16h; Inert atmosphere;

Reference yield:

benzil (134-81-6) → 5-(8-bromo-2,3-di-phenylquinoxalin-5-yl)thiophene-2-carbaldehyde (1313434-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; toluene / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / tetrahydrofuran; water / 4 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In tetrahydrofuran; water; acetic acid; toluene; 2: Suzuki coupling;

DOI:10.1021/ol2012378

upstream raw materials:

3,6-dibromocyclohexa-3,5-diene-1,2-diamine

5,8-dibromo-2,3-diphenylquinoxaline

benzil

1,2-diamine-3,6-dibromobenzene