(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

Base Information

Chemical Name:(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester
CAS No.:1260512-05-7
Molecular Formula:C₁₈H₂₃ClNO₅PS
Molecular Weight:431.877
Hs Code.:

Synonyms:(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

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Chemical Property of (S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

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Technology Process of (S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

There total 8 articles about (S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260511-92-9
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

: 1260512-05-7
(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

Guidance literature:: With trimethylsilyl iodide; for 1h; Inert atmosphere; Cooling with ice;

Reference yield:

: 916516-91-1
4-bromo-2-chloro-1-(2-iodoethyl)benzene

: 1260512-05-7
(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

5.1: carbon tetrabromide; pyridine / 2 h / Cooling with ice

6.1: trimethylsilyl iodide / 1 h / Inert atmosphere; Cooling with ice

With pyridine; hydrogenchloride; lithium borohydride; n-butyllithium; ethanol; trimethylsilyl iodide; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; hexane;

Reference yield:

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

: 1260512-05-7
(S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; diethyl ether / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 12 h / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

3.1: carbon tetrabromide; pyridine / 2 h / Cooling with ice

4.1: trimethylsilyl iodide / 1 h / Inert atmosphere; Cooling with ice

With pyridine; n-butyllithium; trimethylsilyl iodide; carbon tetrabromide; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; diethyl ether; hexane;