(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

Base Information

Chemical Name:(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane
CAS No.:1260511-92-9
Molecular Formula:C₂₇H₃₉ClNO₈PS
Molecular Weight:604.101
Hs Code.:

Synonyms:(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

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Chemical Property of (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

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Technology Process of (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

There total 7 articles about (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260511-77-0
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol

: 121-45-9
phosphorous acid trimethyl ester

: 1260511-92-9
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

Guidance literature:: With pyridine; carbon tetrabromide; for 2h; Cooling with ice;

Reference yield:

: 916516-91-1
4-bromo-2-chloro-1-(2-iodoethyl)benzene

: 1260511-92-9
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.2: 1 h / 20 °C

3.1: lithium borohydride; ethanol / tetrahydrofuran / 2 h / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

5.1: carbon tetrabromide; pyridine / 2 h / Cooling with ice

With pyridine; hydrogenchloride; lithium borohydride; n-butyllithium; ethanol; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; hexane;

Reference yield:

: 25458-49-5
1-(methoxymethoxy)-4-methylbenzene

: 1260511-92-9
(S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-1-dimethoxyphosphoryloxy-2-methylbutane

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; diethyl ether / 1.5 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 12 h / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

3.1: carbon tetrabromide; pyridine / 2 h / Cooling with ice

With pyridine; n-butyllithium; carbon tetrabromide; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; diethyl ether; hexane;