1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

Base Information

Chemical Name:1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione
CAS No.:144266-29-5
Molecular Formula:C₄₂H₄₀N₂O₁₀
Molecular Weight:732.787
Hs Code.:

Synonyms:1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

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Chemical Property of 1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

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Technology Process of 1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

There total 3 articles about 1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79-37-8
oxalyl dichloride

: 133443-76-2,187343-15-3
(2R,4aS,5aS,8R,9aR,9bR)-Perhydro-2,8-diphenyl-2H,5H,8H-bis<1,3>dioxino<5,4-b:4',5'-d>pyrrole

: 144266-29-5
1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)61197-8

Reference yield:

: 28224-73-9
1,3:4,6-di-O-benzylidene-D-mannitol

: 144266-29-5
1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 94 percent / 8 h / 135 °C

3: H₂ / 5percent Pd/C / ethanol / 1 h / Ambient temperature

4: 90 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)61197-8

Reference yield:

: 28224-74-0
1,3:4,6-di-O-benzylidene-2,5-di-O-methanesulfonyl-D-mannitol

: 144266-29-5
1,2-Bis-((2R,4aS,5aS,8R,9aR,9bR)-2,8-diphenyl-hexahydro-bis[1,3]dioxino[5,4-b;4',5'-d]pyrrol-5-yl)-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / 8 h / 135 °C

2: H₂ / 5percent Pd/C / ethanol / 1 h / Ambient temperature

3: 90 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)61197-8