N-tert-Butyl-N-neopentylbenzamide

Base Information

• Chemical Name: N-tert-Butyl-N-neopentylbenzamide
• CAS No.: 132376-91-1
• Molecular Formula: C₁₆H₂₅NO
• Molecular Weight: 247.381
• Mol file: 132376-91-1.mol

Synonyms:N-tert-Butyl-N-neopentylbenzamide

Chemical Property of N-tert-Butyl-N-neopentylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-Butyl-N-neopentylbenzamide

There total 3 articles about N-tert-Butyl-N-neopentylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyltrimethylacetamide (686-96-4) → N-tert-Butyl-N-neopentylbenzamide (132376-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.7 g / LiAlH₄ / ethyl acetate; dibutyl ether / 1 h / Heating

2: 6.1 g / NEt₃ / CHCl₃ / 7 h / Heating

With lithium aluminium tetrahydride; triethylamine; In chloroform; dibutyl ether; ethyl acetate;

DOI:10.1021/jo00005a016

Reference yield:

pivaloyl chloride (3282-30-2) → N-tert-Butyl-N-neopentylbenzamide (132376-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 26.8 g / NEt₃ / CHCl₃ / 4 h / Heating

2: 8.7 g / LiAlH₄ / ethyl acetate; dibutyl ether / 1 h / Heating

3: 6.1 g / NEt₃ / CHCl₃ / 7 h / Heating

With lithium aluminium tetrahydride; triethylamine; In chloroform; dibutyl ether; ethyl acetate;

DOI:10.1021/jo00005a016

Reference yield:

N-t-butyl-2,2-dimethylpropylamine (58471-09-3) + benzoyl chloride (98-88-4) → N-tert-Butyl-N-neopentylbenzamide (132376-91-1)

Guidance literature:

With triethylamine; In chloroform; for 7h; Heating;

DOI:10.1021/jo00005a016

upstream raw materials:

N-t-butyl-2,2-dimethylpropylamine

benzoyl chloride

N-tert-butyltrimethylacetamide

pivaloyl chloride

Downstream raw materials:

N-tert-Butyl-N-neopentylbenzamine