BocNH-PEG7-OH

Base Information

• Chemical Name: BocNH-PEG7-OH
• CAS No.: 1292268-13-3
• Molecular Formula: C₁₉H₃₉NO₉
• Molecular Weight: 425.52
• Mol file: 1292268-13-3.mol

Synonyms:t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate

Chemical Property of BocNH-PEG7-OH

Chemical Property:

• Boiling Point: 521.1±50.0 °C(Predicted)
• PKA: 12.23±0.46(Predicted)
• Density: 1.090±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

BocNH-PEG7-OH min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: N-Boc-PEG7-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of BocNH-PEG7-OH

There total 7 articles about BocNH-PEG7-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate (430430-57-2) + Tetraethylene glycol (112-60-7) → t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-13-3)

Guidance literature:

Tetraethylene glycol; With sodium hydroxide; In water; toluene; at 100 ℃; for 1h;

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate; In water; toluene; at 20 - 100 ℃;

DOI:10.1002/ejoc.201001666

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-13-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 0 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide / water; toluene / 1 h / 100 °C

3.2: 20 - 100 °C

With dmap; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; toluene;

DOI:10.1002/ejoc.201001666

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → t-butyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosylcarbamate (1292268-13-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 0 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

3.1: sodium hydroxide / water; toluene / 1 h / 100 °C

3.2: 20 - 100 °C

With dmap; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; toluene;

DOI:10.1002/ejoc.201001666

upstream raw materials:

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate

Tetraethylene glycol

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

di-tert-butyl dicarbonate

Downstream raw materials:

t-butyl 20-azido-3,6,9,12,15,18-hexaoxaicosylcarbamate

2,2-dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-yl 4-methylbenzenesulfonate

Refernces