(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

Base Information

Chemical Name:(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine
CAS No.:1347702-57-1
Molecular Formula:C₂₄H₃₅NO₂Si
Molecular Weight:397.633
Hs Code.:

Synonyms:(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

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Chemical Property of (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

Chemical Property:

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Technology Process of (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

There total 4 articles about (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1347702-56-0
(2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

: 1347702-57-1
(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃;
DOI:10.1002/chem.201101730

Reference yield:

: 154429-40-0
(2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester

: 1347702-57-1
(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 6.33 h / 0 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0 °C / Reflux

3.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1002/chem.201101730

Reference yield:

: 1347702-55-9
((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

: 1347702-57-1
(2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 °C / Reflux

2.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1002/chem.201101730