((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

Base Information

Chemical Name:((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol
CAS No.:1347702-55-9
Molecular Formula:C₃₀H₃₉NO₂Si
Molecular Weight:473.731
Hs Code.:

Synonyms:((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

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Chemical Property of ((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

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Technology Process of ((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

There total 5 articles about ((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-59-4
phenylmagnesium chloride

: 154429-40-0
(2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid methyl ester

: 1347702-55-9
((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 6.33333h; Inert atmosphere;
DOI:10.1002/chem.201101730

Reference yield:

: 100-39-0
benzyl bromide

: 1347702-55-9
((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / toluene / 6 h / 110 °C

2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 20 °C

3: tetrahydrofuran / 6.33 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201101730

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1347702-55-9
((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 20 °C

2: tetrahydrofuran / 6.33 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/chem.201101730