1347702-55-9Relevant academic research and scientific papers
Palladium-Catalyzed Asymmetric (2+3) Annulation of p-Quinone Methides with Trimethylenemethanes: Enantioselective Synthesis of Functionalized Chiral Spirocyclopentyl p-Dienones
Jia, Zhi-Long,An, Xian-Tao,Deng, Yu-Hua,Wang, Hui-Bin,Gan, Kang-Ji,Zhang, Jing,Zhao, Xian-He,Fan, Chun-An
, p. 4171 - 4175 (2020)
A novel asymmetric catalytic (2+3) annulation of p-quinone methides with CN-substituted trimethylenemethane is described under palladium catalysis, providing an alternative approach for the enantioselective construction of highly functionalized chiral spirocyclopentyl p-dienones. Driven by the significant improvement in the reactivity and enantioselectivity, a novel type of non-C2-symmetric phosphoramidite ligand from the chirality-matched combination of (S)-BINOL and sterically demanding amine derived from l-hydroxyproline is evolved and explored for the protocol presented here.
A new organocatalytic concept for asymmetric -alkylation of aldehydes
Caruana, Lorenzo,Kniep, Florian,Johansen, Tore Kiilerich,Poulsen, Pernille H.,Jorgensen, Karl Anker
, p. 15929 - 15932 (2015/02/19)
The organocatalytic asymmetric -alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts,-diarylmethine-substituted aldehydes with two contiguo
Polystyrene-supported diarylprolinol ethers as highly efficient organocatalysts for Michael-type reactions
Alza, Esther,Sayalero, Sonia,Kasaplar, Pinar,Almasi, Diana,Pericas, Miquel A.
, p. 11585 - 11595 (2011/11/29)
α,α-Diphenylprolinol methyl- and trimethylsilyl ethers anchored onto a polystyrene resin have been prepared by a copper-catalyzed azide-alkyne cycloadditions (CuAAC). The catalytic activity and enantioselectivity displayed by the O-trimethylsilyl derivati
