3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

Base Information

• Chemical Name: 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]
• CAS No.: 213924-46-0
• Molecular Formula: C₂₃H₂₈N₂O
• Molecular Weight: 348.488

Synonyms:3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

Chemical Property of 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

Chemical Property:

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Technology Process of 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

There total 4 articles about 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloroform (67-66-3,8013-54-5) + acetone (67-64-1) + 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine (213924-45-9) → 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] (213924-46-0)

Guidance literature:

With sodium hydroxide; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; at 10 ℃;

DOI:10.1021/jo9808831

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] (213924-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / H₂O / 0.75 h / 15 °C

2: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

3: 96 percent / NaCN, BnEt₃NCl, NaOH / CH₂Cl₂; H₂O / 10 °C

With sodium hydroxide; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; nickel; In ethanol; dichloromethane; water;

DOI:10.1021/jo9808831

Reference yield:

1-nitro-1,2,3,4-tetrahydronaphthalene (79817-66-6) → 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] (213924-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / H₂O / 0.75 h / 15 °C

2: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

3: 96 percent / NaCN, BnEt₃NCl, NaOH / CH₂Cl₂; H₂O / 10 °C

With sodium hydroxide; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; nickel; In ethanol; dichloromethane; water;

DOI:10.1021/jo9808831

upstream raw materials:

chloroform

acetone

1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

(S)-1-phenyl-ethylamine

Downstream raw materials:

(+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]

3',3'-dimethyl-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine]

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