(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

Base Information

Chemical Name:(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine
CAS No.:213924-44-8
Molecular Formula:C₁₉H₂₂N₂O₂
Molecular Weight:310.396
Hs Code.:

Synonyms:(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

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Chemical Property of (1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

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Technology Process of (1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

There total 1 articles about (1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 2627-86-3
(S)-1-phenyl-ethylamine

: 79817-66-6
1-nitro-1,2,3,4-tetrahydronaphthalene

: 213924-44-8
(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

Guidance literature:: In water; at 15 ℃; for 0.75h;
DOI:10.1021/jo9808831

Reference yield: 77.0%

: 213924-44-8
(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

: 213924-45-9
1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine

Guidance literature:: With hydrogen; nickel; In ethanol; at 50 ℃; for 4h; under 25857.4 Torr;
DOI:10.1021/jo9808831

Reference yield:

: 213924-44-8
(1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine

: (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine]-N-oxyl

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / H₂ / Raney-Ni / ethanol / 4 h / 50 °C / 25857.4 Torr

2: 96 percent / NaCN, BnEt₃NCl, NaOH / CH₂Cl₂; H₂O / 10 °C

3: 546 mg / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) reflux, 6 h

4: 79 percent / H₂ / Pearlman' catalyst / methanol / 6 h / 2585.7 Torr

5: 95 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

6: 100 percent / m-CPBA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium hydroxide - carbon; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jo9808831