3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one

Base Information

• Chemical Name: 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one
• CAS No.: 4703-95-1
• Molecular Formula: C8H7 N O2 S2
• Molecular Weight: 213.281
• Hs Code.: 2934999090
• Mol file: 4703-95-1.mol

Synonyms:Rhodanine,3-furfuryl- (8CI); N-Furfurylrhodanine

Chemical Property of 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one

Chemical Property:

• Vapor Pressure: 0.000161mmHg at 25°C
• Boiling Point: 331°Cat760mmHg
• Flash Point: 154°C
• PSA: 90.84000
• Density: 1.49g/cm³
• LogP: 1.57780

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-FURFURYL-RHODANINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one

There total 10 articles about 3-(2-furylmethyl)-2-sulfanylidene-thiazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

carbon disulfide (75-15-0,12122-00-8) + furan-2-ylmethanamine (617-89-0) + methyl N-(chloroacetyl)carbamate (13558-70-8) → 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one (4703-95-1)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 0.166667h;

DOI:10.3390/molecules25051138

Reference yield: 80.0%

carbon disulfide (75-15-0,12122-00-8) + furan-2-ylmethanamine (617-89-0) + chloroacetic acid (79-11-8) → 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one (4703-95-1)

Guidance literature:

carbon disulfide; furan-2-ylmethanamine; With potassium hydroxide; In water; for 0.75h;

chloroacetic acid; With sodium hydrogencarbonate; In water; at 20 ℃; for 96h;

With hydrogenchloride; In water; at 95 ℃; for 1h;

DOI:10.1134/S107042802009016X

Reference yield: 49.0%

carbon disulfide (75-15-0,12122-00-8) + furan-2-ylmethanamine (617-89-0) + ethyl bromoacetate (105-36-2) → 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one (4703-95-1)

Guidance literature:

furan-2-ylmethanamine; With cyanomethanide; In acetonitrile; at -20 ℃; for 1h;

carbon disulfide; In acetonitrile; at -20 ℃; for 1h;

ethyl bromoacetate; In acetonitrile; at -20 - 20 ℃;

DOI:10.1080/17415990903191752

upstream raw materials:

Furan-2-ylmethyl-dithiocarbamic acid; compound with ammonia

chloroacetyl chloride

furan-2-ylmethanamine

sodium monochloroacetic acid

Downstream raw materials:

(Z)-5-(2-(5-chloro-1H-indol-3-yl)-2-oxoethylidene)-3-(furan-2-ylmethyl)-2-thioxothiazolidin-4-one

5-benzylidene-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one

(Z)-5-(2-hydroxybenzylidene)-3-((furan-2-yl)methyl)-2-thioxothiazolidin-4-one

Refernces

• 1、 Krithika, Uma,Prabitha,Mandal, Subhankar P.,Yuvaraj,Priya,Wadhwani, Ashish D.,Prashantha Kumar. "Development of novel rhodanine analogs as anticancer agents: Design, synthesis, evaluation and comsia study". . p. 216 - 229. Retrieved 2021/03/03.
• 2、 Horishny, V. Ya.,Matiychuk, V. S.. "Synthesis and Antitumor Activity of New 5-Ylidene Derivatives of 3-(Furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one". . p. 1600 - 1605. Retrieved 2020/10/22.