C₁₈H₁₈N₆O₄

Base Information

• Chemical Name: C₁₈H₁₈N₆O₄
• CAS No.: 1365759-83-6
• Molecular Formula: C₁₈H₁₈N₆O₄
• Molecular Weight: 382.379
• Mol file: 1365759-83-6.mol

Synonyms:C₁₈H₁₈N₆O₄

Chemical Property of C₁₈H₁₈N₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₈N₆O₄

There total 6 articles about C₁₈H₁₈N₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-(bromoacetyl)morpholine (40299-87-4) + C12H9N5O2 (1365759-77-8) → C18H18N6O4 (1365759-83-6)

Guidance literature:

C₁₂H₉N₅O₂; With sodium hydride; In N,N-dimethyl-formamide; Combinatorial reaction / High throughput screening (HTS);

N-(bromoacetyl)morpholine; In N,N-dimethyl-formamide; at 0 ℃; for 8h; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1021/co200200u

Reference yield:

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) → C18H18N6O4 (1365759-83-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / Combinatorial reaction / High throughput screening (HTS)

1.2: Combinatorial reaction / High throughput screening (HTS)

2.1: acetic acid; zinc / dichloromethane / 0.08 h / 0 °C

3.1: tert.-butylnitrite; trimethylsilylazide / Combinatorial reaction / High throughput screening (HTS)

4.1: trifluoroacetic acid / chloroform / 0 °C / Combinatorial reaction / High throughput screening (HTS)

5.1: sodium hydride / N,N-dimethyl-formamide / Combinatorial reaction / High throughput screening (HTS)

5.2: 8 h / 0 °C / Combinatorial reaction / High throughput screening (HTS)

With tert.-butylnitrite; trimethylsilylazide; sodium hydride; acetic acid; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/co200200u

Reference yield:

t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate (1246303-75-2) → C18H18N6O4 (1365759-83-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: acetic acid; zinc / dichloromethane / 0.08 h / 0 °C

2.1: tert.-butylnitrite; trimethylsilylazide / Combinatorial reaction / High throughput screening (HTS)

3.1: trifluoroacetic acid / chloroform / 0 °C / Combinatorial reaction / High throughput screening (HTS)

4.1: sodium hydride / N,N-dimethyl-formamide / Combinatorial reaction / High throughput screening (HTS)

4.2: 8 h / 0 °C / Combinatorial reaction / High throughput screening (HTS)

With tert.-butylnitrite; trimethylsilylazide; sodium hydride; acetic acid; trifluoroacetic acid; zinc; In dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/co200200u

upstream raw materials:

tert-butyl 2,4-dioxopiperidine-1-carboxylate

N-(bromoacetyl)morpholine

C₁₂H₉N₅O₂

t-butyl 3-(3-nitrophenyl)-4-oxo-6,7-dihydroisoxazolo[4,5-c]pyridine-5(4H)-carboxylate

Downstream raw materials:

C₂₄H₂₅N₇O₄

C₂₇H₂₅N₇O₇

C₂₇H₃₀N₆O₄

C₂₁H₂₂N₆O₅