6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Base Information

• Chemical Name: 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS No.: 1280218-42-9
• Molecular Formula: C₁₈H₁₇F₂N₃O₃S
• Molecular Weight: 393.414

Synonyms:6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Chemical Property of 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Chemical Property:

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Technology Process of 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

There total 4 articles about 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-methyl-1,2-epoxypropane (558-30-5) + 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-22-5) → 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-42-9)

Guidance literature:

6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

2-methyl-1,2-epoxypropane; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 192h;

DOI:10.1021/jm101423y

Reference yield:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) → 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 120 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

2.2: 192 h / 50 - 60 °C

With sodium hydride; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1021/jm101423y

Reference yield:

2-(2,4-difluorophenoxy)acetic acid ethyl ester (717-30-6) → 6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-42-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 120 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

2.2: 192 h / 50 - 60 °C

With sodium hydride; potassium carbonate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1021/jm101423y

upstream raw materials:

2-methyl-1,2-epoxypropane

6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

2-(2,4-difluorophenoxy)acetic acid ethyl ester

Downstream raw materials:

6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one

6-(2,4-difluorophenoxy)-8-(2-hydroxy-2-methylpropyl)-2-(tetrahydropyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

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