Ethyl 2-(2,4-difluorophenoxy)acetate

Base Information

• Chemical Name: Ethyl 2-(2,4-difluorophenoxy)acetate
• CAS No.: 717-30-6
• Molecular Formula: C10H10F2O3
• Molecular Weight: 216.184
• DSSTox Substance ID: DTXSID60403816
• Wikidata: Q82207636
• Mol file: 717-30-6.mol

Synonyms:Ethyl 2-(2,4-difluorophenoxy)acetate;717-30-6;Ethyl 2-(2,4-difluoro-phenoxy)acetate;SCHEMBL13239750;DTXSID60403816;CUIDQZVFXLEWQO-UHFFFAOYSA-N;AKOS003330536;Ethyl2-(2,4-difluoro-phenoxy)acetate;F78615;2-(2,4-difluorophenoxy)acetic acid ethyl ester;2-(2,4-difluorophenoxyl)acetic acid ethyl ester;(2,4-DIFLUOROPHENOXY)-ACETIC ACID ETHYL ESTER

Chemical Property of Ethyl 2-(2,4-difluorophenoxy)acetate

Chemical Property:

• PSA: 35.53000
• LogP: 1.90670
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 216.05980050
• Heavy Atom Count: 15
• Complexity: 211

Purity/Quality:

95% ^*data from raw suppliers

(2,4-DIFLUOROPHENOXY)-ACETICACIDETHYLESTER ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=C(C=C(C=C1)F)F

Technology Process of Ethyl 2-(2,4-difluorophenoxy)acetate

There total 2 articles about Ethyl 2-(2,4-difluorophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,4-difluorophenol (367-27-1) + chloroacetic acid ethyl ester (105-39-5) → 2-(2,4-difluorophenoxy)acetic acid ethyl ester (717-30-6)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Reflux;

DOI:10.1016/j.biopha.2017.08.105

Reference yield:

2,4-difluorophenol (367-27-1) + ethyl bromoacetate (105-36-2) → 2-(2,4-difluorophenoxy)acetic acid ethyl ester (717-30-6)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 3h; Heating;

DOI:10.1016/j.tet.2004.10.019

Reference yield: 85.0%

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) + 2-(2,4-difluorophenoxy)acetic acid ethyl ester (717-30-6) → 6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-22-5)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 16h;

upstream raw materials:

2,4-difluorophenol

ethyl bromoacetate

chloroacetic acid ethyl ester

Downstream raw materials:

<2,4-Difluor-phenoxy>-acethydroxamsaeure

2-(2,4-difluorophenoxy)acetic acid

(2,4-difluoro-phenoxy)-acetyl chloride

[(2,4-difluorophenoxyacetyl)(cyano)methylene]triphenylphosphorane

Refernces

• 1、 Mohammed, Yasser Hussein Eissa,Malojirao, Vikas H.,Thirusangu, Prabhu,Al-Ghorbani, Mohammed,Prabhakar,Khanum, Shaukath Ara. "The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death". . p. 1826 - 1839. Retrieved 2017/11/16.
• 2、 Eissa Mohammed, Yasser Hussein,Thirusangu, Prabhu,Zabiulla,Vigneshwaran,B.T, Prabhakar,Khanum, Shaukath Ara. "The anti-invasive role of novel synthesized pyridazine hydrazide appended phenoxy acetic acid against neoplastic development targeting matrix metallo proteases". . p. 375 - 386. Retrieved 2017/09/02.