1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

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Chemical Name:1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate
CAS No.:553653-11-5
Molecular Formula:C₁₈H₂₄FN₃O₄
Molecular Weight:365.405
Hs Code.:

Synonyms:1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

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Chemical Property of 1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

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Technology Process of 1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

There total 2 articles about 1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 553652-17-8
tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate

: 201230-82-2
carbon monoxide

: 124-40-3
dimethyl amine

: 553653-11-5
1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

Guidance literature:: bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 80 ℃; for 18h;

Reference yield:

: 811788-89-3
4-[(3S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-oxo-1-pyrrolidinyl]-3-fluorobenzoic acid

: 124-40-3
dimethyl amine

: 553653-11-5
1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

Guidance literature:: 4-[(3S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-2-oxo-1-pyrrolidinyl]-3-fluorobenzoic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; for 0.5h;

dimethyl amine; In tetrahydrofuran; acetonitrile; for 17h;