tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate

Base Information

• Chemical Name: tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate
• CAS No.: 553652-17-8
• Molecular Formula: C₁₅H₁₈FIN₂O₃
• Molecular Weight: 420.222

Synonyms:tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate

Chemical Property of tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate

There total 2 articles about tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluro-4-iodoaniline (29632-74-4) + tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate (40856-59-5,132957-40-5) → tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate (553652-17-8)

Guidance literature:

2-fluro-4-iodoaniline; tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate; With trimethylaluminum; In dichloromethane; at 0 - 20 ℃;

With tributylphosphine; di-tert-butyl-diazodicarboxylate; In tetrahydrofuran; dichloromethane; at 20 ℃; Further stages.;

DOI:10.1016/j.bmcl.2007.11.019

Reference yield:

1,1-dimethylethyl ((1S)-1-{[(2-fluoro-4-iodophenyl)amino]carbonyl}-3-hydroxypropyl)-carbamate (553652-15-6) → tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate (553652-17-8)

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

tert-butyl (3S)-1-(2-fluoro-4-iodophenyl)-2-oxopyrrolidin-3-ylcarbamate (553652-17-8) + carbon monoxide (201230-82-2) + dimethyl amine (124-40-3) → 1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate (553653-11-5)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 80 ℃; for 18h;

upstream raw materials:

1,1-dimethylethyl ((1S)-1-{[(2-fluoro-4-iodophenyl)amino]carbonyl}-3-hydroxypropyl)-carbamate

2-fluro-4-iodoaniline

tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

Downstream raw materials:

1,1-dimethylethyl-((3S)-1-{4-[(dimethylamino)carbonyl]-2-fluorophenyl}-2-oxo-3-pyrrolidinyl) carbamate

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