1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

Base Information

Chemical Name:1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one
CAS No.:911285-86-4
Molecular Formula:C₄₅H₃₉IO₈
Molecular Weight:834.704
Hs Code.:

Synonyms:1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

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Chemical Property of 1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

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Technology Process of 1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

There total 10 articles about 1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67052-53-3
4',6'-bis(benzyloxy)-2'-(methoxymethoxy)acetophenone

: 911285-86-4
1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / hydrogen / palladium on carbon / methanol; ethyl acetate / 20 °C

2: 94 percent / iodine; periodic acid / ethanol / 1 h / 40 °C

3: 82 percent / potassium carbonate / dimethylformamide / 1 h / 70 °C

4: potassium hydroxide / ethanol / 1 h / Heating

5: 5.48 g / aq. HCl / ethanol; CHCl₃ / 1 h / 40 °C

6: 88 percent / potassium carbonate / dimethylformamide / 0.5 h / 60 - 70 °C

7: [hydroxy(tosyloxy)iodo]benzene / CHCl₃ / 24 h / 20 °C

With hydrogenchloride; potassium hydroxide; [hydroxy(tosyloxy)iodo]benzene; hydrogen; iodine; potassium carbonate; periodic acid; palladium on activated charcoal; In methanol; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1080/00397910500514121

Reference yield:

: 67-56-1
methanol

: 4,2',4'-tris(benzyloxy)-6'-benzoyloxy-3'-iodochalcone

: 911285-86-4
1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

Guidance literature:: With toluene-4-sulfonic acid; Poly[4-(diacetoxy)iodo]styrene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1055/s-2002-35617

Reference yield:

: 18065-05-9
1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone

: 911285-86-4
1-[6-benzoyloxy-2,4-bis(benzyloxy)-3'-iodophenyl]-2-[4-benzyloxyphenyl]-3,3-dimethyloxypropan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / H₂ / Pd/C / methanol; ethyl acetate / 20 °C

2: 96 percent / I₂; periodic acid / ethanol; H₂O / 0.03 h / 45 °C / microwave irradiation

3: 82 percent / K₂CO₃ / dimethylformamide / 1 h / 70 °C

4: KOH / ethanol / 0.1 h / 88 °C / microwave irradiation

5: 5.99 g / aq. HCl / methanol; CHCl₃ / 1 h / 40 °C

6: 91 percent / pyridine / 0.08 h / 125 °C / microwave irradiation

7: [hydroxy(tosyloxy)iodo]benzene / CHCl₃ / 0.2 h / 60 °C / microwave irradiation

With pyridine; hydrogenchloride; potassium hydroxide; [hydroxy(tosyloxy)iodo]benzene; hydrogen; iodine; potassium carbonate; periodic acid; palladium on activated charcoal; In methanol; ethanol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.06.066