[2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester
CAS No.:122832-87-5
Molecular Formula:C₁₂H₁₈BNO₅
Molecular Weight:267.09
Hs Code.:
DSSTox Substance ID:DTXSID501189606
Nikkaji Number:J880.545H

Synonyms:SCHEMBL8574647;NSRTWHFMZQMDGF-UHFFFAOYSA-N;DTXSID501189606;122832-87-5;tert-Butyl 2-Borono-4-methoxycarbanilate;C-(1,1-Dimethylethyl) N-(2-borono-4-methoxyphenyl)carbamate;[2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester

Suppliers and Price of [2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of [2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester

Chemical Property:

Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:267.1278028
Heavy Atom Count:19
Complexity:305

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:B(C1=C(C=CC(=C1)OC)NC(=O)OC(C)(C)C)(O)O

Technology Process of [2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester

There total 6 articles about [2-(Dihydroxyboryl)-4-methoxyphenyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: methanol-dichloromethane

: 121-43-7,63156-11-6
Trimethyl borate

: 18437-68-8
tert-butyl N-(4-methoxyphenyl)carbamate

: 122832-87-5
(2-((tert-butoxycarbonyl)amino)-5-methoxyphenyl)boronic acid

Guidance literature:: With tert.-butyl lithium; In pentane;

Reference yield: 55.0%

: 121-43-7,63156-11-6
Trimethyl borate

: 18437-68-8
tert-butyl N-(4-methoxyphenyl)carbamate

: 122832-87-5
(2-((tert-butoxycarbonyl)amino)-5-methoxyphenyl)boronic acid

Guidance literature:: With tert.-butyl lithium; ammonium chloride; In diethyl ether; (Ar); stirring (-20°C, 5 min, 23°C, 12 h); extn. (etyl acetate), drying (sodium sulphate), concn.;
DOI:10.1021/ja9703741

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 122832-87-5
(2-((tert-butoxycarbonyl)amino)-5-methoxyphenyl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / tetrahydrofuran / 20 °C

2.1: tert-butyllithium / diethyl ether / -20 °C

2.2: diethyl ether

3.1: NH₄Cl; H₂O / 20 °C

With water; tert.-butyl lithium; ammonium chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1055/s-2006-956482