4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane

Base Information

• Chemical Name: 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane
• CAS No.: 958640-43-2
• Molecular Formula: C₁₄H₂₃BrOSi
• Molecular Weight: 315.326
• Mol file: 958640-43-2.mol

Synonyms:4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane

Chemical Property of 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane

There total 3 articles about 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(4-bromophenyl)-2-methyl-2-butanol (87077-84-7) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane (958640-43-2)

Guidance literature:

With iodine; In dichloromethane; for 1h;

DOI:10.1021/jo7015289

Reference yield:

4-(4-bromophenyl)-2-butanone (89201-84-3) → 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane (958640-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / diethyl ether / 4 h / 20 °C

2: 70 percent / iodine / CH₂Cl₂ / 1 h

With iodine; In diethyl ether; dichloromethane;

DOI:10.1021/jo7015289

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → 4-(4-bromophenyl)-2-methyl-2-trimethylsiloxybutane (958640-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / potassium carbonate / ethanol / 16 h / Heating

2: 81 percent / diethyl ether / 4 h / 20 °C

3: 70 percent / iodine / CH₂Cl₂ / 1 h

With iodine; potassium carbonate; In diethyl ether; ethanol; dichloromethane;

DOI:10.1021/jo7015289

upstream raw materials:

4-(4-bromophenyl)-2-methyl-2-butanol

1,1,1,3,3,3-hexamethyl-disilazane

4-(4-bromophenyl)-2-butanone

1-bromomethyl-4-bromobenzene