{(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester

Base Information

• Chemical Name: {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester
• CAS No.: 785027-07-8
• Molecular Formula: C₂₇H₃₂N₄O₅S
• Molecular Weight: 524.641
• Mol file: 785027-07-8.mol

Synonyms:{(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester

Chemical Property of {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester

There total 17 articles about {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)acetate (290332-76-2) → {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester (785027-07-8)

Guidance literature:

ethyl (N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)acetate; With hydrogenchloride; In ethanol; chloroform; at 5 ℃; for 30h;

With ammonium acetate; In ethanol; chloroform; at 20 ℃; for 16h;

DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester (785027-07-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran

2.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

3.1: NaBH(OAc)3; AcOH / CH₂Cl₂

4.1: pyridine

5.1: NH₂OH / ethanol

6.1: acetic anhydride; acetic acid

6.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

7.1: TFA / CH₂Cl₂

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00927-7

Reference yield:

tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate (138227-62-0) → {(7-carbamimidoyl-naphthalen-2-ylmethyl)-[4-(piperidin-4-yloxy)-phenyl]-sulfamoyl}-acetic acid ethyl ester (785027-07-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: H₂ / 10 percent Pd/C / methanol / 760 Torr

2.1: NaBH(OAc)3; AcOH / CH₂Cl₂

3.1: pyridine

4.1: NH₂OH / ethanol

5.1: acetic anhydride; acetic acid

5.2: H₂ / 10 percent Pd/C / methanol / 760 Torr

6.1: TFA / CH₂Cl₂

With pyridine; hydrogen; hydroxylamine; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

DOI:10.1016/S0960-894X(02)00927-7

upstream raw materials:

ethyl (N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)acetate

4-{4-[(7-carbamimidoyl-naphthalen-2-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester

7-methyl-2-naphthalene carbonitrile

7-methoxy-2-naphthol

Downstream raw materials:

YM-60828

Ethyl (N-{4-[(1-Acetimidoyl-4-piperidyl)oxy]phenyl}-N-[(7-amidino-2-naphthyl)methyl]sulfamoyl)acetate