3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

Base Information

Chemical Name:3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate
CAS No.:364356-56-9
Molecular Formula:C₆₃H₆₅N₄O₁₄PSSe
Molecular Weight:1244.23
Hs Code.:

Synonyms:3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

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Chemical Property of 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

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Technology Process of 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

There total 2 articles about 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 76054-81-4
3'-O-(4,4'-dimethoxytrityl)thymidine

: 183295-17-2
5'-O-dimethoxytrityl-thymidine-3'-O-(2-seleno-1,3,2-dithiaphospholane)

: 74-88-4
methyl iodide

: 364356-56-9
3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

Guidance literature:: 3'-O-(4,4'-dimethoxytrityl)thymidine; 5'-O-dimethoxytrityl-thymidine-3'-O-(2-seleno-1,3,2-dithiaphospholane); With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 1h;

methyl iodide; In acetonitrile; for 1h;
DOI:10.1016/S0968-0896(01)00025-6

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 364356-56-9
3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-tetrazole / CH₂Cl₂ / 1 h

1.2: 74 percent / Se / CH₂Cl₂ / 12 h

2.1: DBU / acetonitrile / 1 h

2.2: 75 percent / acetonitrile / 1 h

With 1H-tetrazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1016/S0968-0896(01)00025-6

Reference yield: 56.0%

: 364356-56-9
3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphorothioselenoate

: 191977-95-4
3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorothiofluoridate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine hydrofluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1016/S0968-0896(01)00025-6