5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile
• CAS No.: 851707-82-9
• Molecular Formula: C₁₈H₁₃FN₄O
• Molecular Weight: 320.326

Synonyms:5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile

Chemical Property of 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile

Chemical Property:

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Technology Process of 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile

There total 3 articles about 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone (357952-79-5) + 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile (42754-61-0) → 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile (851707-82-9)

Guidance literature:

With sodium carbonate; In acetonitrile; for 3h; Heating;

DOI:10.1081/SCC-200049761

Reference yield: 75.0%

2-bromo-4'-fluoroacetophenone (403-29-2) + 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile (42754-61-0) → 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile (851707-82-9)

Guidance literature:

With sodium carbonate; In acetonitrile; for 10h; Heating;

DOI:10.1081/SCC-200049761

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 5-amino-1-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-phenyl-1H-pyrazole-4-carbonitrile (851707-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 0.75 h / Heating

2: 88 percent / sodium carbonate / acetonitrile / 3 h / Heating

With sodium carbonate; In acetonitrile;

DOI:10.1081/SCC-200049761

upstream raw materials:

2-bromo-4'-fluoroacetophenone

5-amino-3-phenyl-1H-pyrazole-4-carbonitrile

1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone

1-(4-fluorophenyl)ethanone

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