4-nitrophenyl camptothecin-10-yl carbonate

Base Information

• Chemical Name: 4-nitrophenyl camptothecin-10-yl carbonate
• CAS No.: 656233-42-0
• Molecular Formula: C₂₇H₁₉N₃O₉
• Molecular Weight: 529.463
• Mol file: 656233-42-0.mol

Synonyms:4-nitrophenyl camptothecin-10-yl carbonate

Chemical Property of 4-nitrophenyl camptothecin-10-yl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-nitrophenyl camptothecin-10-yl carbonate

There total 1 articles about 4-nitrophenyl camptothecin-10-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-10-hydroxycamptothecin (19685-09-7,64439-81-2) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrophenyl camptothecin-10-yl carbonate (656233-42-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; Schlenk technique;

DOI:10.1039/c8nj06191b

Reference yield: 73.0%

4-nitrophenyl camptothecin-10-yl carbonate (656233-42-0) + 4-piperidinopiperidin (4897-50-1) → 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (103816-16-6)

Guidance literature:

With triethylamine; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2005.06.039

Reference yield: 72.0%

1-[4-(cis-4,7,10,13,16,19-docosahexenoyl)amino]benzylpiperazine (656233-41-9) + 4-nitrophenyl camptothecin-10-yl carbonate (656233-42-0) → 10-[4-[[4-(cis-4,7,10,13,16,19-docosahexenoyl)amino]benzyl]-1-piperazino]carbonyloxy-camptothecin (656233-43-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2005.06.039

upstream raw materials:

(S)-10-hydroxycamptothecin

4-Nitrophenyl chloroformate

Downstream raw materials:

10-[4-[[4-(cis-4,7,10,13,16,19-docosahexenoyl)amino]benzyl]-1-piperazino]carbonyloxy-camptothecin

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin