cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

Base Information

Chemical Name:cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine
CAS No.:691880-04-3
Molecular Formula:C₂₄H₂₈N₂O
Molecular Weight:360.499
Hs Code.:

Synonyms:cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

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Chemical Property of cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

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Technology Process of cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

There total 7 articles about cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691880-05-4
3-(2-((trimethylsilyl)oxy)ethyl)-1H-indole

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: trans-4-(dimethylamino)-4-phenyl-4',9'-dihydro-3’H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]

: 691880-04-3
cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 - 20 ℃; for 15.0833h; Inert atmosphere;
DOI:10.1021/ml500116x

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 691880-04-3
cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; water

2.1: tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / water

4.1: dichloromethane

With hydrogenchloride; In tetrahydrofuran; methanol; dichloromethane; water; 1.1: |Strecker Aminoacid Synthesis / 2.1: |Bruylants Amination / 4.1: |Pictet-Spengler Synthesis;
DOI:10.1021/ml500116x

Reference yield:

: 65619-92-3
8-(dimethylamino)-1,4-dioxaspiro-[4.5]-decane-8-carbonitrile

: 691880-04-3
cis-4',9'-dihydro-N,N-dimethyl-4-phenyl-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 - 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / water

3.1: dichloromethane

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water; 1.1: |Bruylants Amination / 3.1: |Pictet-Spengler Synthesis;
DOI:10.1021/ml500116x