65619-92-3

Usage

Uses

Used in Pharmaceutical Industry:
8-DiMethylaMino-1,4-dioxaspiro[4.5]decan-8-carbonitrile is used as a key intermediate in the synthesis of a series of potent analgesics. Its unique chemical structure contributes to the development of effective pain-relieving medications, making it a valuable compound in the field of pharmaceuticals.
Used in Pain Management:
8-DiMethylaMino-1,4-dioxaspiro[4.5]decan-8-carbonitrile is utilized in the preparation of analgesics for pain management. Its incorporation into the development of these medications aids in providing relief from various types of pain, including chronic and acute pain conditions.

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 506-59-2 N,N-dimethylammonium chloride 
• 151-50-8 potassium cyanide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 124-40-3 dimethyl amine 
• 637-88-7 1,4-Cyclohexanedione 

Downstream Products

• 80165-54-4 Dimethyl-{8-[3-(tetrahydro-pyran-2-yloxy)-phenyl]-1,4-dioxa-spiro[4.5]dec-8-yl}-amine 
• 76626-24-9 3-(4-Benzyl-1-dimethylamino-4-hydroxy-cyclohexyl)-phenol 
• 70895-07-7 3-(1-Dimethylamino-4-hydroxy-4-phenethyl-cyclohexyl)-phenol 
• 70895-08-8 3-(1-Dimethylamino-4-hydroxy-4-phenethyl-cyclohexyl)-phenol 
• 70895-11-3 3-{4-[2-(4-Chloro-phenyl)-ethyl]-1-dimethylamino-4-hydroxy-cyclohexyl}-phenol 
• 70895-12-4 3-{4-[2-(4-Chloro-phenyl)-ethyl]-1-dimethylamino-4-hydroxy-cyclohexyl}-phenol 
• 76626-21-6 3-(1-Dimethylamino-4-hydroxy-cyclohexyl)-phenol 
• 65619-94-5 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal 
• 76626-23-8 3-(1-Dimethylamino-4-hydroxy-4-methyl-cyclohexyl)-phenol 
• 76626-22-7 3-(1-Dimethylamino-4-hydroxy-4-methyl-cyclohexyl)-phenol 
• 65618-70-4 4-(p-chlorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal hydrochloride 
• 65619-96-7 4-(m-trifluoromethylphenyl)-4-dimethylaminocyclohexanone ethylene ketal hydrochloride 
• 65619-19-4 4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride 
• 1002916-55-3 Dimethyl-(8-m-tolyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amine hydrochloride 

Relevant academic research and scientific papers

3-(Carboxyethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives

The invention relates to 3-(carboxyethyl)-8-amino-2-oxo-1,3-diazaspiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-((HETERO-)ARYL)-ALKYL-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES

The invention relates to 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives

The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives

The invention relates to 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

3-((HETERO-)ARYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES

The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES

The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Discovery of a potent analgesic NOP and opioid receptor agonist: Cebranopadol

In a previous communication, our efforts leading from 1 to the identification of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amine 2a as analgesic NOP and opioid receptor agonist were disclosed and their favorable in vitro and in vivo pharmacological properties revealed. We herein report our efforts to further optimize lead 2a, toward trans-6′-fluoro-4′, 9′-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1′(3′H) -pyrano[3,4-b]indol]-4-amine (cebranopadol, 3a), which is currently in clinical development for the treatment of severe chronic nociceptive and neuropathic pain.

Discovery of spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as potent NOP and opioid receptor agonists

We report the discovery of spiro[cyclohexane-pyrano[3,4-b]indole]-amines, as functional nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonists with strong efficacy in preclinical models of acute and neuropathic pain. Utilizing 4-(dimethylamino)-4-phenylcyclo-hexanone 1 and tryptophol in an oxa-Pictet-Spengler reaction led to the formation of spiroether 2, representing a novel NOP and opioid peptide receptor agonistic chemotype. This finding initially stems from the systematic derivatization of 1, which resulted in alcohols 3-5, ethers 6 and 7, amines 8-10, 22-24, and 26-28, amides 11 and 25, and urea 12, many with low nanomolar binding affinities at the NOP and mu opioid peptide (MOP) receptors.

Spirocyclic Cyclohexane Compounds

Spirocyclic cyclohexane compounds corresponding to formula I In which R1, R2, R3 and R5 through R10 and X have defined meanings, a process for their preparation, pharmaceutical compositions containing such compounds, and the use of such spirocyclic cyclohexane compounds in the treatment and/or inhibition of pain and other conditions mediated by the ORL-1 or the ?-opioid receptor.

Substituted Spiroamine Compounds

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.