NH-bis(PEG1-OH)

Base Information

• Chemical Name: NH-bis(PEG1-OH)
• CAS No.: 54384-47-3
• Molecular Formula: C₈H₁₉NO₄
• Molecular Weight: 193.243
• European Community (EC) Number: 847-789-5
• DSSTox Substance ID: DTXSID301156253
• Nikkaji Number: J1.482.629G
• Mol file: 54384-47-3.mol

Synonyms:54384-47-3;NH-bis(PEG1-OH);NH-bis-PEG2;2-(2-([2-(2-Hydroxyethoxy)ethyl]amino)ethoxy)ethan-1-ol;MFCD00239212;2-(2-{[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol;2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))bis(ethan-1-ol);2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))diethanol;SCHEMBL720627;DTXSID301156253;6-aza-3,9-dioxaundecane-1,11-diol;AKOS011787526;37099-91-5;BP-23224;SY344981;HY-130328;CS-0107320;NS00095415;C70248;EN300-7378103;2-[2-[2-(2-hydroxyethoxy)ethylamino]ethoxy]ethanol;2,2 inverted exclamation mark -[[Azanediylbis(ethane-2,1-diyl)]bis(oxy)]diethanol

Chemical Property of NH-bis(PEG1-OH)

Chemical Property:

• Boiling Point: 128 °C(Press: 0.02 Torr)
• PKA: 14.09±0.10(Predicted)
• Density: 1.090±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DCM, DMF
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 193.13140809
• Heavy Atom Count: 13
• Complexity: 82.2

Purity/Quality:

97% ^*data from raw suppliers

NH-bis(PEG1-OH) 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(COCCO)NCCOCCO
• Description: NH-bis(PEG1-OH) can be used to conjugate with carboxylic acid in the presence of HATU or EDC

Technology Process of NH-bis(PEG1-OH)

There total 5 articles about NH-bis(PEG1-OH) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,2'-(((benzylazanediyl)bis(ethane-2,1-diyl))bis(oxy))diethanol (119580-47-1) → 2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))diethanol (54384-47-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1039/c1nj20523d

Reference yield: 84.0%

2-(2-Aminoethylamino)ethanol (111-41-1) + 2-(2-Chloroethoxy)ethanol (628-89-7) → tris-[2-(2-hydroxy-ethoxy)-ethyl]-amine (54384-48-4) + 2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))diethanol (54384-47-3)

Guidance literature:

With sodium carbonate; In butan-1-ol; for 1.5h; Heating;

DOI:10.1016/S0040-4020(01)88367-8

Reference yield: 79.0%

2-(2-Chloroethoxy)ethanol (628-89-7) + 2-(2-Aminoethoxy)ethanol (929-06-6) → 2,2'-((azanediylbis(ethane-2,1-diyl))bis(oxy))diethanol (54384-47-3)

Guidance literature:

With sodium carbonate; In toluene; for 48h; Heating;

DOI:10.1021/jo00124a022

upstream raw materials:

2-(2-Chloroethoxy)ethanol

2-(2-Aminoethylamino)ethanol

2-(2-Aminoethoxy)ethanol

2,2'-(((benzylazanediyl)bis(ethane-2,1-diyl))bis(oxy))diethanol

Downstream raw materials:

N,N-bis<2-<2-<(p-tolylsulfonyl)oxy>ethoxy>ethyl>-p-toluenesulfonamide

10-(4-Methylphenylsulfonyl)-1,7-dioxa-4-thia-10-azacyclododecane

4,10,13-tris-(4-tolylsulphonyl)-1,7-dioxa-4,10,13-triazacylopentadecane

tert-butyl bis(2-(2-hydroxyethoxy)ethyl)carbamate