2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

Base Information

Chemical Name:2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine
CAS No.:844856-99-1
Molecular Formula:C₃₂H₃₉NO₅
Molecular Weight:517.665
Hs Code.:

Synonyms:2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

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Chemical Property of 2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

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Technology Process of 2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

There total 6 articles about 2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 844856-98-0
[2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 844856-99-1
2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

Guidance literature:: [2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester; With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; In dichloromethane; at 0 - 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1021/jo0483567

Reference yield:

: 100-39-0
benzyl bromide

: 844856-99-1
2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C / Cooling with ice

2.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 1 h / 0 °C

2.2: 0 °C

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; tetra-(n-butyl)ammonium iodide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol301331t

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 844856-99-1
2-benzyloxy-2-(8-benzyloxy-1,4-dioxaspiro[4.5]dec-7-yl)-1-(4-methoxybenzyl)ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: iPr₂NH; n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.3: 56 percent / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.1: 71 percent / Bu₄NI; Ag₂O / 12 h / 20 °C

3.1: 2,6-lutidine; TBDMSOTf / CH₂Cl₂ / 0 - 20 °C

3.2: 96 percent / TBAF / tetrahydrofuran / 0.17 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; t-butyldimethylsiyl triflate; tetra-(n-butyl)ammonium iodide; diisopropylamine; silver(l) oxide; In tetrahydrofuran; hexane; dichloromethane; 2.1: Luche reduction;
DOI:10.1021/jo0483567