(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

Base Information

Chemical Name:(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester
CAS No.:128766-84-7
Molecular Formula:C₁₈H₁₉FNO₃PS
Molecular Weight:379.392
Hs Code.:

Synonyms:(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

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Chemical Property of (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

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Technology Process of (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

There total 4 articles about (4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 371-62-0
2-fluoroethanol

: 104608-47-1
ethyl (4-benzothiazol-2-ylbenzyl)phosphonochloridate hydrochloride

: 128766-84-7
(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1248/cpb.38.676

Reference yield:

: 24239-18-7
2-<4-(bromomethyl)phenyl>benzothiazole

: 128766-84-7
(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 0.6 g / 0.25 h / 130 - 140 °C

2: 1) NaOH, 2) 1N HCl / 1) EtOH, reflux, 3 h; 2) pH 1.5

3: SOCl₂

4: 79 percent / Et₃N / tetrahydrofuran

With hydrogenchloride; sodium hydroxide; thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1248/cpb.38.676

Reference yield:

: 75889-62-2
fostedil

: 128766-84-7
(4-Benzothiazol-2-yl-benzyl)-phosphonic acid ethyl ester 2-fluoro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaOH, 2) 1N HCl / 1) EtOH, reflux, 3 h; 2) pH 1.5

2: SOCl₂

3: 79 percent / Et₃N / tetrahydrofuran

With hydrogenchloride; sodium hydroxide; thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1248/cpb.38.676