2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

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Chemical Name:2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione
CAS No.:1456901-35-1
Molecular Formula:C₂₈H₂₇N₅O₇
Molecular Weight:545.552
Hs Code.:

Synonyms:2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

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Chemical Property of 2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

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Technology Process of 2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

There total 4 articles about 2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 32366-25-9
1-azidoethylbenzene

: 1255792-08-5
3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

: 1456901-35-1
2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

Guidance literature:: With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(I) bromide; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1246/cl.130235

Reference yield:

: 1255792-05-2
1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol

: 1456901-35-1
2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide; pyridine / tetrahydrofuran; benzene / 12.5 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

2.2: 3 h / 50 °C / Inert atmosphere

3.1: copper(I) bromide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With pyridine; N,N,N',N'',N'''-pentamethyldiethylenetriamine; phosphorus tribromide; potassium carbonate; copper(I) bromide; In tetrahydrofuran; N,N-dimethyl-formamide; benzene; 3.1: |Huisgen Cycloaddition;
DOI:10.1246/cl.130235

Reference yield:

: 1255792-04-1
1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

: 1456901-35-1
2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 °C

2.1: phosphorus tribromide; pyridine / tetrahydrofuran; benzene / 12.5 h / 0 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

3.2: 3 h / 50 °C / Inert atmosphere

4.1: copper(I) bromide; N,N,N',N'',N'''-pentamethyldiethylenetriamine / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; N,N,N',N'',N'''-pentamethyldiethylenetriamine; phosphorus tribromide; potassium carbonate; copper(I) bromide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene; 4.1: |Huisgen Cycloaddition;
DOI:10.1246/cl.130235