3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

Base Information

• Chemical Name: 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne
• CAS No.: 1255792-08-5
• Molecular Formula: C₂₀H₁₈N₂O₇
• Molecular Weight: 398.372
• Mol file: 1255792-08-5.mol

Synonyms:3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

Chemical Property of 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne

There total 3 articles about 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,6-epoxy-1,2,3,6-tetrahydrophthalimide (6253-28-7,19878-26-3,42074-03-3) + 1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide (1456901-32-8) → 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne (1255792-08-5)

Guidance literature:

3,6-epoxy-1,2,3,6-tetrahydrophthalimide; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide; at 50 ℃; for 3h; Inert atmosphere;

DOI:10.1246/cl.130235

Reference yield:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol (1255792-05-2) → 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne (1255792-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus tribromide; pyridine / tetrahydrofuran; benzene / 12.5 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

2.2: 3 h / 50 °C / Inert atmosphere

With pyridine; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

DOI:10.1246/cl.130235

Reference yield:

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one (1255792-04-1) → 3-(2-methoxy-5-nitro-4-(1-(oxabicyclo[2,2,1]hept-5-enedicarboxyimide)ethyl)phenoxy)-1-propyne (1255792-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 °C

2.1: phosphorus tribromide; pyridine / tetrahydrofuran; benzene / 12.5 h / 0 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

3.2: 3 h / 50 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;

DOI:10.1246/cl.130235

upstream raw materials:

3,6-epoxy-1,2,3,6-tetrahydrophthalimide

1-(5-methoxy-2-nitro-4-prop-2-ynyloxyphenyl)ethyl bromide

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-one

1-(5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)phenyl)ethan-1-ol

Downstream raw materials:

2-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-1H-pyrrole-2,5-dione

1-(1-(5-methoxy-2-nitro-4-((1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethyl)-3-(octylthio)pyrrolidine-2,5-dione