((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester
CAS No.:212266-66-5
Molecular Formula:C₂₈H₃₃NO₅S
Molecular Weight:495.64
Hs Code.:

Synonyms:((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

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Chemical Property of ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

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Technology Process of ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

There total 1 articles about ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-39-0
benzyl bromide

: 116611-44-0
((R)-2-benzenesulfonyl-1-hydroxymethyl-ethyl)carbamic acid tert-butyl ester

: 212266-66-5
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 ℃; for 24h;
DOI:10.1016/S0040-4039(98)01171-X

Reference yield: 95.0%

: 212266-66-5
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

: 212266-67-6
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-amine

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01171-X

Reference yield:

: 212266-66-5
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-carbamic acid tert-butyl ester

: 212266-65-4
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / 3M HCl / ethyl acetate / 1 h / Ambient temperature

2: 97 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / Ambient temperature

3: 94 percent / 4M HCl / tetrahydrofuran / 3 h / Ambient temperature

4: 85 percent / pyridine / 24 h / 0 °C

5: 99 percent / K₂CO₃ / H₂O; dimethylformamide / 24 h / Ambient temperature

6: 1.) Ti(Oi-Pr)4, 2.) KHMDS / 1.) THF, -78 deg C, 10 min, 2.) -70 deg C, 2 h

7: 95 percent / H₂ / Pd/C / methanol / Ambient temperature

8: 96 percent / 6percent Na-Hg, Na₂HPO₄ / methanol / 2 h / 0 °C

With pyridine; titanium(IV) isopropylate; hydrogenchloride; disodium hydrogenphosphate; sodium amalgam; hydrogen; potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01171-X