Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester

Base Information

Chemical Name:Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester
CAS No.:74531-87-6
Molecular Formula:C13H12N2O3S
Molecular Weight:276.311
Hs Code.:
DSSTox Substance ID:DTXSID60225535
Nikkaji Number:J405.896H
Wikidata:Q83104533
ChEMBL ID:CHEMBL280302

Synonyms:74531-87-6;Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester;F 1863;Ethyl N-(4-phenylthiazol-2-yl)oxamate;Oxamic acid, N-(4-phenyl-2-thiazolyl)-, ethyl ester;Ethyl ((4-phenyl-2-thiazolyl)amino)oxoacetate;(Phenyl-4 thiazolyl-2) oxamate d'ethyle [French];(Phenyl-4 thiazolyl-2) oxamate d'ethyle;ethyl 2-oxo-2-[(4-phenyl-1,3-thiazol-2-yl)amino]acetate;CHEMBL280302;N-(4-Phenyl-thiazol-2-yl)-oxalamic acid ethyl ester;SCHEMBL11139118;DTXSID60225535;STL362970;STL568613;AKOS000624413;AKOS037624865;FT-0752152;AB00098137-01;ethyl oxo[(4-phenyl-1,3-thiazol-2-yl)amino]acetate;2-[[4-Phenylthiazol-2-yl]amino]-2-oxoacetic acid ethyl ester;ethyl oxo{[(2E)-4-phenyl-1,3-thiazol-2(3H)-ylidene]amino}acetate

Suppliers and Price of Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester

Chemical Property:

Density:1.334g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:276.05686342
Heavy Atom Count:19
Complexity:332

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=O)NC1=NC(=CS1)C2=CC=CC=C2

Technology Process of Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester

There total 3 articles about Acetic acid, ((4-phenyl-2-thiazolyl)amino)oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 2010-06-2
2-Amino-4-phenylthiazole

: 95-92-1
oxalic acid diethyl ester

: 74531-87-6
N-(4-Phenyl-thiazol-2-yl)-oxalamic acid ethyl ester

Guidance literature:: With sodium ethanolate; In tetrahydrofuran; ethanol; for 1.5h; Ambient temperature;
DOI:10.1055/s-1991-26569

Reference yield: 58.0%

: 2010-06-2
2-Amino-4-phenylthiazole

: 4755-77-5
Ethyl oxalyl chloride

: 74531-87-6
N-(4-Phenyl-thiazol-2-yl)-oxalamic acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 3h; Ambient temperature;

Reference yield:

: 98-86-2
acetophenone

: 74531-87-6
N-(4-Phenyl-thiazol-2-yl)-oxalamic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Br₂ / 1.) dioxane, dichloroethane, 2 h: 60-70 deg C, 4 h: reflux; 2.) 2 h: 60-70 deg C, 4 h: reflux

2: 58 percent / triethylamine / tetrahydrofuran / 3 h / Ambient temperature

With bromine; triethylamine; In tetrahydrofuran;