1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine

Base Information

Chemical Name:1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine
CAS No.:333364-08-2
Molecular Formula:C₂₇H₃₁FN₂
Molecular Weight:402.555
Hs Code.:
DSSTox Substance ID:DTXSID001149726
Nikkaji Number:J1.524.594H
ChEMBL ID:CHEMBL39262

Synonyms:CHEMBL39262;SCHEMBL1476523;DTXSID001149726;BDBM50098392;1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine;(2,2-Diphenyl-ethyl)-[1-(4-fluoro-benzyl)-piperidin-4-ylmethyl]-amine;N-(2,2-Diphenylethyl)-1-[(4-fluorophenyl)methyl]-4-piperidinemethanamine;333364-08-2

Suppliers and Price of 1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine

Chemical Property:

XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:402.24712716
Heavy Atom Count:30
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1CNCC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=C(C=C4)F

Technology Process of 1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine

There total 4 articles about 1-(4-Fluorobenzyl)-4-(2,2-diphenylethylaminomethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 333364-06-0
4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine

: 333364-08-2
4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: With borane; In tetrahydrofuran; for 6h; Heating;
DOI:10.1021/jm000311k

Reference yield:

: 3963-62-0
2,2-Diphenylethylamine

: 333364-08-2
4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: 81 percent / BH₃ / tetrahydrofuran / 6 h / Heating

With borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k

Reference yield:

: 193538-25-9
1-(4-Fluorobenzyl)piperidine-4-carboxylic acid

: 333364-08-2
4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: 81 percent / BH₃ / tetrahydrofuran / 6 h / Heating

With borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k