4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine

Base Information

• Chemical Name: 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine
• CAS No.: 333364-06-0
• Molecular Formula: C₂₇H₂₉FN₂O
• Molecular Weight: 416.538
• Mol file: 333364-06-0.mol

Synonyms:4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine

Chemical Property of 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine

There total 2 articles about 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Diphenylethylamine (3963-62-0) + 1-(4-Fluorobenzyl)piperidine-4-carboxylic acid (193538-25-9) → 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine (333364-06-0)

Guidance literature:

1-(4-Fluorobenzyl)piperidine-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

2,2-Diphenylethylamine; In dichloromethane; at 20 ℃; Further stages.;

DOI:10.1021/jm000311k

Reference yield:

1-[(4-Fluorophenyl)methyl]-4-(ethoxycarbonyl)-piperidine (193538-24-8) → 4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine (333364-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: CF₃CO₂H; aq. HCl / 2 h / Heating

2.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

2.2: CH₂Cl₂ / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm000311k

Reference yield: 81.0%

4-[(2-diphenylethyl)aminocarbonyl]-1-[(4-fluorophenyl)methyl]piperidine (333364-06-0) → 4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine (333364-08-2)

Guidance literature:

With borane; In tetrahydrofuran; for 6h; Heating;

DOI:10.1021/jm000311k

upstream raw materials:

2,2-Diphenylethylamine

1-(4-Fluorobenzyl)piperidine-4-carboxylic acid

1-[(4-Fluorophenyl)methyl]-4-(ethoxycarbonyl)-piperidine

Downstream raw materials:

4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine