4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Base Information

Chemical Name:4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine
CAS No.:333363-92-1
Molecular Formula:C₂₈H₃₃FN₂
Molecular Weight:416.582
Hs Code.:

Synonyms:4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Suppliers and Price of 4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

There total 5 articles about 4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 333364-08-2
4-[(2-diphenylethyl)aminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

: 333363-92-1
4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: With formic acid; for 3h; Heating;
DOI:10.1021/jm000311k

Reference yield:

: 3963-62-0
2,2-Diphenylethylamine

: 333363-92-1
4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: 81 percent / BH₃ / tetrahydrofuran / 6 h / Heating

3.1: 88 percent / aq. formic acid / 3 h / Heating

With formic acid; borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k

Reference yield:

: 193538-25-9
1-(4-Fluorobenzyl)piperidine-4-carboxylic acid

: 333363-92-1
4-[[2-(diphenyl)ethyl]-N-methylaminomethyl]-1-[(4-fluorophenyl)methyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: EDCI; HOBT / CH₂Cl₂ / 1 h / 20 °C

1.2: CH₂Cl₂ / 20 °C

2.1: 81 percent / BH₃ / tetrahydrofuran / 6 h / Heating

3.1: 88 percent / aq. formic acid / 3 h / Heating

With formic acid; borane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000311k