3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

Base Information

Chemical Name:3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid
CAS No.:1242328-90-0
Molecular Formula:C₂₂H₁₉N₃O₅
Molecular Weight:405.41
Hs Code.:

Synonyms:3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

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Chemical Property of 3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

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Technology Process of 3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

There total 8 articles about 3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 7647-01-0,15364-23-5
hydrogenchloride

: 67-56-1
methanol

: 1242329-45-8
3-({6-[(6-chloropyridin-3-yl)oxy]-1-methyl-1H-benzimidaol-2-yl}methoxy)benzoic acid

: 1242328-90-0
3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

Guidance literature:: methanol; 3-({6-[(6-chloropyridin-3-yl)oxy]-1-methyl-1H-benzimidaol-2-yl}methoxy)benzoic acid; With sodium hydride; In mineral oil; for 2h; Reflux; Microwave irradiation;

hydrogenchloride; In water;

Reference yield: 79.0%

: 67-56-1
methanol

: 1242329-45-8
3-({6-[(6-chloropyridin-3-yl)oxy]-1-methyl-1H-benzimidaol-2-yl}methoxy)benzoic acid

: 1242328-90-0
3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

Guidance literature:: With sodium hydride; In mineral oil; at 150 ℃; for 2h; Microwave irradiation;
DOI:10.1021/acsmedchemlett.8b00645

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1242328-90-0
3-({6-[(6-methoxypyridin-3-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / 10 h / 80 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 5 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C / Inert atmosphere

4: 4 h / 80 °C / Acidic conditions

5: sodium hydroxide; water / 1,4-dioxane / 2 h / 80 °C

6: sodium hydride / mineral oil / 2 h / 150 °C / Microwave irradiation

With water; iron; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; mineral oil;
DOI:10.1021/acsmedchemlett.8b00645